Patterns:
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Endocrine and metabolic abnormalities in myotonic dystrophy type 1 (DM1) are well documented.
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Hyperinsulinemia following glucose ingestion show glucose and glycated hemoglobin (HbA1c) values typical of prediabetes or impaired glucose tolerance.
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Increased incidence of thyroid, parathyroid and gonadal dysfunction, along with abnormal blood levels of some adrenal hormones.
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Gonadal insufficiency contributes to problems of erectile dysfunction, infertility, and diminished ovarian reserve.
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Women may experience reduced fertility, spontaneous abortion and stillbirth, and they may have a somewhat higher rate of excessively painful and irregular menstruations than the general population.
Symptoms:
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Painful or irregular menses.
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Erectile dysfunction.
Diagnosis:
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Discuss the following tests with your doctor:
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Liver enzymes and bilirubin levels.
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Thyroid function - TSH and free T4 levels.
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Hyperlipidemia.
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Reproductive and fertility/infertility history - irregular menses; ovarian cysts; endometriosis.
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Treatment:
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Refer to OB-GYN specialist as appropriate.
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Family planning.
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Refer to genetic counselor or other specialists as indicated.
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Minoxidil (Rogaine) for hair loss.
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Lifestyle changes in diet and exercise and appropriate use of medications to normalize blood glucose and insulin levels for treatment of insulin resistance.
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Consider possible cardiovascular side-effects with some erectile dysfunction medications.